Oral testosterone treatment
LOW TESTOSTERONE
Treatment information guide
Low testosterone treatment works best with expert oversight and regular monitoring. That’s why we provide end-to-end clinical care, from diagnosis through to personalised, ongoing care.
All treatments require ongoing clinical supervision, regular blood monitoring, and dose adjustments based on individual response.
Explore our treatment options
We provide personalised care to ensure each patient receives the most effective treatment for their needs.
Oral testosterone treatment
We provide two different oral approaches to treating low testosterone. One replaces testosterone to bring levels back to normal, while the other encourages your body to produce more of its own. The right option depends on your symptoms, blood results, and long-term goals.
Oral TRT
Kyzatrex
| Treatment | Kyzatrex |
|---|---|
| Overview | An oral TRT taken as capsules with food. It works by directly replacing testosterone in men with clinically confirmed low levels, helping restore levels back into the normal range |
| Usage | Taken twice daily with meals |
| Efficacy | In a six-month clinical study of 139 men with low testosterone, 96% of participants who completed treatment achieved testosterone levels within the normal reference range.¹ |
| Benefits | A needle-free alternative to injectable testosterone and avoids the skin contact risks associated with gels. Kyzatrex is absorbed via the lymphatic system rather than undergoing first-pass metabolism in the liver.² |
| Limitations | It must be taken twice daily. Kyzatrex can increase blood pressure and red blood cell counts in some men, which is why regular blood testing, blood pressure monitoring, and clinician supervision are essential.¹ |
| Monthly price | From £149 |
FAQS
Kyzatrex FAQs
Oral testosterone optimisation
Clomiphene
| Treatment | Clomiphene |
|---|---|
| Overview | Clomiphene is an oral medication that works differently from traditional testosterone replacement therapy. Instead of supplying testosterone directly, it stimulates your body’s own natural production, which may help preserve fertility in some men. It can also be prescribed alongside TRT to continue to stimulate natural testicular testosterone production and maintain testicular volume. |
| Usage | Clomiphene is typically taken once daily, although dosing is personalised based on blood test results and symptoms. |
| Efficacy | In a study of 125 men with low testosterone and low libido, taking 25 mg of clomiphene daily increased testosterone levels from 10.7 nmol/L to 23.2 nmol/L over three months.³ |
| Benefits | Because clomiphene stimulates the natural hormone axis, it does not suppress sperm production and may be more suitable for men who wish to preserve fertility. It is taken orally, avoids injections or gels, and in clinical studies has shown meaningful improvements in testosterone levels and sexual wellbeing.³ |
| Limitations | Clomiphene is not appropriate for all causes of low testosterone, particularly in men with primary testicular failure where the testes cannot respond to stimulation. It's also not suitable for men with liver disease and can increase seizures in men with epilepsy. |
| Monthly price | From £89/monotherapy | £19/TRT add-on |
FAQS
Clomiphene FAQs
Injectable testosterone treatment
We provide two different oral approaches to treating low testosterone. One replaces testosterone to bring levels back to normal, while the other encourages your body to produce more of its own. The right option depends on your symptoms, blood results, and long-term goals.
Injectable TRT
Testosterone cypionate
| Treatment | Testosterone cypionate |
|---|---|
| Overview | Testosterone cypionate is an injectable form of testosterone replacement therapy (TRT). It’s used to restore testosterone levels in men with confirmed testosterone deficiency, under clinician supervision. |
| Usage | Usually injected into fatty areas of the body on a schedule agreed with your clinician. This is commonly prescribed as a set dose to be injected 2-3 times a week.⁴ |
| Efficacy | In a clinical study of 234 men with low testosterone, weekly testosterone cypionate injections increased average testosterone levels from around 10.9 nmol/L to 18.6 nmol/L within 12 weeks, bringing many men back into the normal range.⁴ |
| Benefits | It’s taken as a small self-administered injection 2–3 times per week, typically in the morning. Testosterone cypionate is designed for safe use at home following clinician guidance, and we provide all necessary syringes and wipes. This dosing approach helps maintain steadier testosterone levels compared with traditional intramuscular injections. |
| Limitations | It’s a widely used option with flexible dosing schedules. More frequent dosing can help some men feel steadier week to week by avoiding bigger hormonal highs and lows. As it is an injection, you are at greater risk of developing an injection-site reaction. A doctor letter would also be required if you were to travel with your medication. This can be provided free-of-charge as part of your subscription. |
| Monthly price | £129 |
FAQS
Injectable TRT FAQs
Injectable testosterone optimisation
Human chorionic gonadotropin (HCG)
| Treatment | Human Chorionic Gonadotropin hormone |
|---|---|
| Overview | Zivafert contains human chorionic gonadotropin (hCG), which stimulates the testicles to produce more of your own testosterone. hCG can also be prescribed alongside TRT to continue to stimulate natural testicular testosterone production and maintain testicular volume. |
| Usage | hCG is given as a subcutaneous injection, typically 2-3 times per week. |
| Efficacy | In a study of 42 men with testosterone deficiency, most participants experienced improvement in hormone levels and reported improvement in symptoms. On average, total testosterone levels increased substantially (by about 709 ng/dL).⁵ In a smaller review of men treated for low testosterone symptoms, 86% reported improved erections and 80% reported improved libido, with no clotting events observed.⁶ |
| Benefits | hCG helps the body produce its own testosterone rather than replacing it. Because of this, it may help preserve fertility and testicular size in some men. It also poses less risk of blood clotting than TRT. |
| Limitations | Treatment typically requires multiple injections per week, which some people find less convenient than other options. Side effects such as nipple sensitivity or breast swelling were reported in a small number of patients but often improved with dose adjustment or additional treatment. The medication will need to be kept in the fridge, and a doctor letter would also be required if you were to travel with your medication. This can be provided free-of-charge as part of your subscription. |
| Monthly price | From £174/monotherapy | £54/TRT add-on |
FAQS
hCG FAQs
Topical testosterone treatment
We offer topical testosterone treatment designed to restore testosterone levels in men with clinically confirmed deficiency. These treatments deliver testosterone through the skin to help bring levels back into a healthy range.
Topical TRT
Testogel
| Treatment | Testogel |
|---|---|
| Overview | A prescription testosterone gel applied to the skin each day to help restore testosterone to a healthy range in men with clinically confirmed low testosterone. |
| Usage | Applied once daily to clean, dry, intact skin (typically shoulders/upper arms). Allow it to dry fully over 3-5 minutes, then cover with clothing. Wash hands after applying. |
| Efficacy | In a 1-year clinical study of a higher-strength testosterone gel (1.62%), most men were able to reach testosterone levels in the normal adult range with dose adjustments. By the final visit (day 364), around 78% of men who had been on the gel throughout had average testosterone levels in the normal range, and around 87% of men who started the gel later (after placebo) reached normal levels once their dose was titrated.⁶ |
| Benefits | Testosterone gel is well tolerated. Its dose can be adjusted based on blood results and symptoms. Some studies suggest a lower incidence of elevated haematocrit compared with injectable formulations.⁷ |
| Limitations | Daily routine required; skin-to-skin transfer risk if precautions aren’t followed (especially to partners/children); some people find gels messy or dislike the feel/smell; absorption can vary between individuals. |
| Monthly price | From £99 |
FAQS
Testogel FAQs
Digital clinic
Testosterone treatment ad-ons
Your treatment can be expanded with targeted add-ons that provide deeper insight and greater flexibility. Choose from fertility-focused options and convenient diagnostics, all integrated into your care plan.
hCG add-on
From £54
Supports your body’s natural testosterone production to help reduce testicular shrinkage and may help preserve fertility in some men.
Clomid add-on
From £19
Encourages your body to produce more of its own testosterone, and may help preserve fertility and sperm production in some men.
Sperm testing
£84.99
Check your sperm health from home with ExSeed, which provides information about key sperm parameters, helping you better understand your fertility status.
Digital clinic
The Numan TRT Programme
Our TRT Programme brings together everything needed to treat low testosterone safely and effectively. We handle the diagnostics, clinical assessments, personalised treatment, and routine follow-ups so your care stays on track and built around your needs, supporting your progress over time.
STEP 1
Diagnosing Low-T
You’ll complete two nurse-led venous blood tests (from under £100) to accurately assess your testosterone levels. Our doctors then review your results with you in a consultation to confirm whether you have Low-T and whether the Numan TRT Programme is right for you.
STEP 2
Starting treatment
Following diagnosis, your clinician will recommend and prescribe treatment aligned to your goals, concerns, and preferences. Fertility considerations and future plans are carefully factored in, and we’ll confirm your ongoing monthly supply so your treatment starts smoothly and stays consistent.
STEP 3
Ongoing care
With structured reviews at 1, 3, 6, and 12 months, plus follow-up blood tests, we track how well your treatment is working and adjust when needed. You can speak to a clinician whenever questions come up, with ongoing support included as part of your treatment plan.
Results
What results to expect when you start TRT
Clinical studies have observed that as testosterone levels increase, some men report gradual improvements in areas such as energy, mood and sexual wellbeing over time. Changes don’t happen overnight, and everyone responds differently, but treatment is designed to support steady, clinically-monitored progress.8
Month 1-3
Increased libido
Improved energy and mood
Better erectile function
Month 3-6
Improved strength
Increased lean muscle mass
Sharper focus and motivation
Month 6 onwards
Faster recovery
Improved bone density
Visceral fat reduction
FAQS
Your questions answered
References
Kyzatrex prescribing information. Fda.gov. [accessed 20 Feb 2026] Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/213953s000lbl.pdf
Asghar AA, Hashmi MR, Ahmed R, Khabir Y. Kyzatrex - Oral testosterone replacement therapy. Ann Med Surg (Lond). 2022;82(104625):104625.
Da Ros CT, Averbeck MA. Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study. Int Braz J Urol. 2012;38(4):512–8.
Choi EJ, Xu P, Barham D, El-Khatib FM, Yafi FA, Kavoussi PK. Comparison of outcomes for hypogonadal men treated with intramuscular testosterone cypionate versus subcutaneous testosterone enanthate. J Urol. 2022;207(3):677–83.
Zucker I, Rainer Q, Pai RK, Ramasamy R, Masterson TA. Efficacy and safety of human chorionic gonadotropin monotherapy for men with hypogonadal symptoms and normal testosterone. Cureus. 2022;14(5):e25543.
Madhusoodanan V, Patel P, Lima TFN, Gondokusumo J, Lo E, Thirumavalavan N, et al. Human Chorionic Gonadotropin monotherapy for the treatment of hypogonadal symptoms in men with total testosterone > 300 ng/dL. Int Braz J Urol. 2019;45(5):1008–12.
Kaufman JM, Miller MG, Fitzpatrick S, McWhirter C, Brennan JJ. One-year efficacy and safety study of a 1.62% testosterone gel in hypogonadal men: results of a 182-day open-label extension of a 6-month double-blind study. J Sex Med. 2012;9(4):1149–61.
El-Osta A, Liu VN, Huang D, Foster J, Johnson H, Alaa A, et al. A cross-sectional survey of experiences and outcomes of using testosterone replacement therapy in UK men. Translational andrology and urology. 2025;14(5): 1295–1307
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