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Hunger hormones: understanding ghrelin, leptin, and regulating your appetite

By Joe Young | Medically reviewed by Ruth Pointon
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When it comes to your health, it’s easy to overlook one critical area: your hunger hormones. Ghrelin and leptin play crucial roles in regulating hunger and fullness. Understanding what these hormones are and how they work can help you manage your appetite effectively.

Why understanding ghrelin and leptin matters

Many of us are guilty of ignoring our bodies’ signals. We eat out of habit, boredom, or stress rather than true hunger. Understanding ghrelin and leptin can help break this cycle. By paying attention to these hormones, you can make more informed decisions about when and what to eat.

Let’s take a closer look at how they work:

Ghrelin: the hunger hormone

Ghrelin is produced primarily in the stomach. Its main function is to signal the brain that it’s time to eat. When your stomach is empty, ghrelin levels rise, sending hunger signals to your brain.

  • How ghrelin works:

    • Ghrelin travels through the bloodstream to the brain, particularly to the hypothalamus, the area that regulates appetite.

    • As ghrelin levels increase, you feel hungrier and are more likely to seek out food.

    • After eating, ghrelin levels decrease, reducing the hunger signals and helping you feel satisfied.

Leptin: the satiety hormone

Leptin, known as the "satiety hormone," is produced by fat cells. Its primary role is to regulate energy balance by inhibiting hunger, thereby promoting the sensation of fullness after eating.

  • How leptin works:

    • Leptin communicates with the hypothalamus to signal that the body has enough energy stored and that it doesn’t need more food.

    • Higher levels of leptin reduce appetite and increase energy expenditure.

    • Low levels of leptin can lead to increased hunger and reduced energy expenditure, signalling the body to eat more.

So you can see how mastering these hormones can be beneficial in controlling your eating habits. 

Now let’s see how:

7 practical steps to manage hunger hormones

Prioritise sleep 

Sleep is essential for hormone and weight regulation. Poor sleep disrupts ghrelin and leptin levels, making you feel hungrier and less satisfied after meals. Studies highlight the importance of ghrelin and leptin in weight management and overall health. For instance, one study found that individuals who slept only four hours per night had a 28% increase in ghrelin levels and an 18% decrease in leptin levels compared to those who slept for ten hours. 

Eat a balanced diet 

A diet rich in protein, fibre, and healthy fats can help regulate hunger hormones. Protein increases feelings of fullness and reduces ghrelin levels. Fibre slows digestion, helping you feel fuller for longer. Healthy fats are essential for hormone production and balance. Research shows that diet plays a crucial role in hormone regulation. For example, a high-protein breakfast reduces ghrelin levels more effectively than a high-carbohydrate breakfast, suggesting that including more protein in your diet can help control hunger.

Exercise regularly 

Physical activity has a positive impact on hormone levels. Regular exercise can help reduce ghrelin levels and increase leptin sensitivity. Aim for at least 150 minutes of moderate-intensity exercise each week.

Manage stress 

Chronic stress disrupts hormone balance and increases ghrelin levels. Incorporate stress management techniques such as exercise or getting outside into your routine. Or try something more outside of the box. Studies demonstrate that chronic stress increases cortisol levels, leading to increased food intake and weight gain. 

Stay hydrated 

Dehydration can sometimes be mistaken for hunger. Drink plenty of water throughout the day to stay hydrated. This can help reduce unnecessary snacking and overeating.

Regular eating schedule 

Maintaining a regular eating schedule can significantly help regulate ghrelin levels and prevent extreme hunger, which often leads to overeating. A study on patients with anorexia indicated that irregular eating patterns, such as skipping meals, can cause spikes in ghrelin levels, leading to increased hunger and a higher likelihood of overeating at subsequent meals​.

Additionally, eating smaller, more frequent meals throughout the day can help maintain stable blood sugar levels, preventing the quick spikes and drops that can increase ghrelin and cause hunger.

Avoid sugary foods 

Avoiding sugary foods can help maintain hormonal balance, particularly for ghrelin and insulin. Research indicates that excessive sugar intake can lead to rapid spikes in blood sugar levels, which in turn can cause insulin resistance and disrupt ghrelin secretion. Ghrelin is intricately linked with insulin, and maintaining stable insulin levels is crucial for keeping ghrelin in check. 

By reducing sugar consumption, you can help stabilise insulin levels, which may prevent excessive ghrelin production and help manage hunger and energy balance more effectively​.

To help manage your hunger hormones more effectively, choose healthy snacks that are high in protein and fibre. Foods like nuts, yoghurt, and fruits are excellent options because they provide sustained energy and help you feel full longer. 

The numan take

By understanding ghrelin and leptin, you can make informed decisions about your diet and lifestyle. This knowledge enables you to take control of your hunger. More balanced hormones will help you feel fuller, reduce cravings, and improve your health.

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